Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1666986..1667625 Replicon chromosome
Accession NZ_LS483429
Organism Haemophilus aegyptius strain NCTC8502

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag DQN49_RS08720 Protein ID WP_005650215.1
Coordinates 1667320..1667625 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQN49_RS08715 Protein ID WP_005650217.1
Coordinates 1666986..1667309 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN49_RS10250 1662606..1662779 - 174 WP_005657572.1 DUF5363 domain-containing protein -
DQN49_RS08700 1662776..1664746 - 1971 WP_006995880.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQN49_RS08705 1664751..1665092 - 342 WP_006995879.1 SirB2 family protein -
DQN49_RS08710 1665153..1666823 - 1671 WP_005663485.1 energy-dependent translational throttle protein EttA -
DQN49_RS08715 1666986..1667309 - 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
DQN49_RS08720 1667320..1667625 - 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN49_RS08725 1667950..1668570 + 621 WP_005694310.1 zinc transporter binding subunit ZevA -
DQN49_RS08730 1668573..1669547 + 975 WP_006995878.1 zinc transporter permease subunit ZevB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T292561 WP_005650215.1 NZ_LS483429:c1667625-1667320 [Haemophilus aegyptius]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT292561 WP_005650217.1 NZ_LS483429:c1667309-1666986 [Haemophilus aegyptius]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References