292558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 494669..496017 Replicon chromosome
Accession NZ_LS483429
Organism Haemophilus aegyptius strain NCTC8502

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag DQN49_RS02660 Protein ID WP_006995245.1
Coordinates 494986..496017 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag DQN49_RS02655 Protein ID WP_006995246.1
Coordinates 494669..494989 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN49_RS02615 489892..490170 + 279 WP_006995251.1 cell division protein FtsB -
DQN49_RS02620 490170..490847 + 678 WP_006995250.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DQN49_RS02625 490844..491320 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
DQN49_RS10180 491390..491557 - 168 WP_006995248.1 hypothetical protein -
DQN49_RS02630 491824..492258 - 435 WP_006995247.1 D-tyrosyl-tRNA(Tyr) deacylase -
DQN49_RS02635 492255..492695 - 441 WP_005667635.1 FMN-binding protein MioC -
DQN49_RS02640 492792..493010 - 219 WP_005650820.1 cell division protein ZapB -
DQN49_RS02645 493172..494173 + 1002 WP_005672749.1 class II fructose-bisphosphatase -
DQN49_RS02650 494373..494681 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
DQN49_RS02655 494669..494989 + 321 WP_006995246.1 type II toxin-antitoxin system HipA family toxin Antitoxin
DQN49_RS02660 494986..496017 + 1032 WP_006995245.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN49_RS02665 496101..497759 - 1659 WP_006995244.1 thiol reductant ABC exporter subunit CydC -
DQN49_RS02670 497752..499497 - 1746 WP_006995243.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39718.31 Da        Isoelectric Point: 6.5777

>T292558 WP_006995245.1 NZ_LS483429:494986-496017 [Haemophilus aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12452.13 Da        Isoelectric Point: 6.3254

>AT292558 WP_006995246.1 NZ_LS483429:494669-494989 [Haemophilus aegyptius]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRIN
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References