292548

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1798180..1798713 Replicon chromosome
Accession NZ_LS483423
Organism Jonesia denitrificans strain NCTC10816

Toxin (Protein)


Gene name yoeB Uniprot ID C7QYS0
Locus tag DQN74_RS08395 Protein ID WP_015771937.1
Coordinates 1798180..1798434 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7QYS1
Locus tag DQN74_RS08400 Protein ID WP_015771938.1
Coordinates 1798435..1798713 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN74_RS08370 1793239..1795020 + 1782 WP_015771933.1 thiol reductant ABC exporter subunit CydC -
DQN74_RS08375 1795086..1796291 + 1206 WP_105597338.1 GAF domain-containing protein -
DQN74_RS08380 1796301..1796924 - 624 WP_015771935.1 response regulator transcription factor -
DQN74_RS08385 1797070..1798038 + 969 WP_015771936.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit -
DQN74_RS08395 1798180..1798434 - 255 WP_015771937.1 Txe/YoeB family addiction module toxin Toxin
DQN74_RS08400 1798435..1798713 - 279 WP_015771938.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DQN74_RS08405 1798667..1799041 + 375 WP_083775133.1 hypothetical protein -
DQN74_RS08410 1798977..1799528 + 552 WP_015771939.1 GNAT family N-acetyltransferase -
DQN74_RS08415 1799539..1800468 - 930 WP_015771940.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
DQN74_RS08420 1800475..1801215 - 741 WP_049754459.1 ribonuclease III -
DQN74_RS08425 1801238..1801432 - 195 WP_015771942.1 50S ribosomal protein L32 -
DQN74_RS08430 1801435..1801926 - 492 WP_083775215.1 DUF177 domain-containing protein -
DQN74_RS08435 1802133..1802636 - 504 WP_105597337.1 hypothetical protein -
DQN74_RS08440 1802715..1803197 - 483 WP_015771946.1 pantetheine-phosphate adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.50 Da        Isoelectric Point: 6.7175

>T292548 WP_015771937.1 NZ_LS483423:c1798434-1798180 [Jonesia denitrificans]
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10366.60 Da        Isoelectric Point: 5.7185

>AT292548 WP_015771938.1 NZ_LS483423:c1798713-1798435 [Jonesia denitrificans]
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C7QYS0

Antitoxin

Source ID Structure
AlphaFold DB C7QYS1

References