Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1798180..1798713 Replicon chromosome
Accession NZ_LS483423
Organism Jonesia denitrificans strain NCTC10816

Toxin (Protein)


Gene name yoeB Uniprot ID C7QYS0
Locus tag DQN74_RS08395 Protein ID WP_015771937.1
Coordinates 1798180..1798434 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7QYS1
Locus tag DQN74_RS08400 Protein ID WP_015771938.1
Coordinates 1798435..1798713 (-) Length 93 a.a.

Genomic Context

DQN74_RS08370DQN74_RS08375DQN74_RS08385DQN74_RS08405DQN74_RS08410DQN74_RS08380DQN74_RS08395DQN74_RS08400DQN74_RS08415DQN74_RS08420DQN74_RS08425DQN74_RS08430DQN74_RS08435DQN74_RS08440
Location: 1793239..1795020 (1782 bp)
Type: Others
Protein ID: WP_015771933.1
Location: 1795086..1796291 (1206 bp)
Type: Others
Protein ID: WP_105597338.1
Location: 1797070..1798038 (969 bp)
Type: Others
Protein ID: WP_015771936.1
Location: 1798667..1799041 (375 bp)
Type: Others
Protein ID: WP_083775133.1
Location: 1798977..1799528 (552 bp)
Type: Others
Protein ID: WP_015771939.1
Location: 1796301..1796924 (624 bp)
Type: Others
Protein ID: WP_015771935.1
Location: 1798180..1798434 (255 bp)
Type: Toxin
Protein ID: WP_015771937.1
Location: 1798435..1798713 (279 bp)
Type: Antitoxin
Protein ID: WP_015771938.1
Location: 1799539..1800468 (930 bp)
Type: Others
Protein ID: WP_015771940.1
Location: 1800475..1801215 (741 bp)
Type: Others
Protein ID: WP_049754459.1
Location: 1801238..1801432 (195 bp)
Type: Others
Protein ID: WP_015771942.1
Location: 1801435..1801926 (492 bp)
Type: Others
Protein ID: WP_083775215.1
Location: 1802133..1802636 (504 bp)
Type: Others
Protein ID: WP_105597337.1
Location: 1802715..1803197 (483 bp)
Type: Others
Protein ID: WP_015771946.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DQN74_RS083701793239..1795020+1782WP_015771933.1thiol reductant ABC exporter subunit CydC-
DQN74_RS083751795086..1796291+1206WP_105597338.1GAF domain-containing protein-
DQN74_RS083801796301..1796924-624WP_015771935.1response regulator transcription factor-
DQN74_RS083851797070..1798038+969WP_015771936.1D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit-
DQN74_RS083951798180..1798434-255WP_015771937.1Txe/YoeB family addiction module toxinToxin
DQN74_RS084001798435..1798713-279WP_015771938.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
DQN74_RS084051798667..1799041+375WP_083775133.1hypothetical protein-
DQN74_RS084101798977..1799528+552WP_015771939.1GNAT family N-acetyltransferase-
DQN74_RS084151799539..1800468-930WP_015771940.1bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase-
DQN74_RS084201800475..1801215-741WP_049754459.1ribonuclease III-
DQN74_RS084251801238..1801432-195WP_015771942.150S ribosomal protein L32-
DQN74_RS084301801435..1801926-492WP_083775215.1DUF177 domain-containing protein-
DQN74_RS084351802133..1802636-504WP_105597337.1hypothetical protein-
DQN74_RS084401802715..1803197-483WP_015771946.1pantetheine-phosphate adenylyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.50 Da        Isoelectric Point: 6.7175

>T292548 WP_015771937.1 NZ_LS483423:c1798434-1798180 [Jonesia denitrificans]
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10366.60 Da        Isoelectric Point: 5.7185

>AT292548 WP_015771938.1 NZ_LS483423:c1798713-1798435 [Jonesia denitrificans]
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7QYS0

Antitoxin

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Source
ID
Structure
AlphaFold DBC7QYS1

References