Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1504107..1504762 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name higB Uniprot ID A0A4D7IZ57
Locus tag DQN80_RS06540 Protein ID WP_068909942.1
Coordinates 1504107..1504463 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B7JJ80
Locus tag DQN80_RS06545 Protein ID WP_068909944.1
Coordinates 1504463..1504762 (+) Length 100 a.a.

Genomic Context


DQN80_RS06525DQN80_RS06530DQN80_RS06535DQN80_RS06540DQN80_RS06545DQN80_RS06550DQN80_RS06555DQN80_RS06560
Location: 1499682..1500722 (1041 bp)
Type: Others
Protein ID: WP_068909938.1
Location: 1500919..1501917 (999 bp)
Type: Others
Protein ID: WP_068445556.1
Location: 1502163..1503794 (1632 bp)
Type: Others
Protein ID: WP_068909940.1
Location: 1504107..1504463 (357 bp)
Type: Toxin
Protein ID: WP_068909942.1
Location: 1504463..1504762 (300 bp)
Type: Antitoxin
Protein ID: WP_068909944.1
Location: 1504845..1506299 (1455 bp)
Type: Others
Protein ID: WP_068909946.1
Location: 1506313..1507476 (1164 bp)
Type: Others
Protein ID: WP_068909947.1
Location: 1507532..1508422 (891 bp)
Type: Others
Protein ID: WP_068909949.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DQN80_RS065251499682..1500722+1041WP_068909938.1galactose-1-epimerase-
DQN80_RS065301500919..1501917+999WP_068445556.1substrate-binding domain-containing protein-
DQN80_RS065351502163..1503794+1632WP_068909940.1sodium/sugar symporter-
DQN80_RS065401504107..1504463+357WP_068909942.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DQN80_RS065451504463..1504762+300WP_068909944.1helix-turn-helix domain-containing proteinAntitoxin
DQN80_RS065501504845..1506299-1455WP_068909946.1bifunctional 2-methylcitrate dehydratase/aconitate hydratase-
DQN80_RS065551506313..1507476-1164WP_068909947.12-methylcitrate synthase-
DQN80_RS065601507532..1508422-891WP_068909949.1methylisocitrate lyase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-108)

Antitoxin

(32-84)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13976.32 Da        Isoelectric Point: 9.5588

>T292541 WP_068909942.1 NZ_LS483422:1504107-1504463 [Providencia heimbachae]
MTWKITTRPLFEAWFEEQNEAVQEETLSVLNILREYGPYIGRPQVDTLKDSKYRNMKELRIQVGGHPIRICFVFDPMRKG
VILCAGNKKGHDEKRFYSKLIRLADMEYSIYLKGIYKI

Download         Length: 357 bp


Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11138.08 Da        Isoelectric Point: 10.0092

>AT292541 WP_068909944.1 NZ_LS483422:1504463-1504762 [Providencia heimbachae]
MGTLEELLAKRSPESLKRIEARVEELRREITLSKMREELNISQVQLAESLGIKQPAVVKMEKLGNDPKLSTIKRYVKALG
GELSLDVTLSNGKKLELHL

Download         Length: 300 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A4D7IZ57


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B7JJ80

References