Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1504107..1504762 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name higB Uniprot ID A0A4D7IZ57
Locus tag DQN80_RS06540 Protein ID WP_068909942.1
Coordinates 1504107..1504463 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B7JJ80
Locus tag DQN80_RS06545 Protein ID WP_068909944.1
Coordinates 1504463..1504762 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS06525 1499682..1500722 + 1041 WP_068909938.1 galactose-1-epimerase -
DQN80_RS06530 1500919..1501917 + 999 WP_068445556.1 substrate-binding domain-containing protein -
DQN80_RS06535 1502163..1503794 + 1632 WP_068909940.1 sodium/sugar symporter -
DQN80_RS06540 1504107..1504463 + 357 WP_068909942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN80_RS06545 1504463..1504762 + 300 WP_068909944.1 helix-turn-helix domain-containing protein Antitoxin
DQN80_RS06550 1504845..1506299 - 1455 WP_068909946.1 bifunctional 2-methylcitrate dehydratase/aconitate hydratase -
DQN80_RS06555 1506313..1507476 - 1164 WP_068909947.1 2-methylcitrate synthase -
DQN80_RS06560 1507532..1508422 - 891 WP_068909949.1 methylisocitrate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13976.32 Da        Isoelectric Point: 9.5588

>T292541 WP_068909942.1 NZ_LS483422:1504107-1504463 [Providencia heimbachae]
MTWKITTRPLFEAWFEEQNEAVQEETLSVLNILREYGPYIGRPQVDTLKDSKYRNMKELRIQVGGHPIRICFVFDPMRKG
VILCAGNKKGHDEKRFYSKLIRLADMEYSIYLKGIYKI

Download         Length: 357 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11138.08 Da        Isoelectric Point: 10.0092

>AT292541 WP_068909944.1 NZ_LS483422:1504463-1504762 [Providencia heimbachae]
MGTLEELLAKRSPESLKRIEARVEELRREITLSKMREELNISQVQLAESLGIKQPAVVKMEKLGNDPKLSTIKRYVKALG
GELSLDVTLSNGKKLELHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7IZ57

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JJ80

References