Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 744331..744901 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name higB Uniprot ID A0A1B7JQL3
Locus tag DQN80_RS03215 Protein ID WP_068909369.1
Coordinates 744331..744612 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A1B7JQM8
Locus tag DQN80_RS03220 Protein ID WP_068439151.1
Coordinates 744623..744901 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS03195 740718..741950 + 1233 WP_068909366.1 multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR -
DQN80_RS03200 742025..743692 - 1668 WP_068909368.1 energy-dependent translational throttle protein EttA -
DQN80_RS03215 744331..744612 + 282 WP_068909369.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN80_RS03220 744623..744901 + 279 WP_068439151.1 HigA family addiction module antidote protein Antitoxin
DQN80_RS03225 745111..747027 + 1917 WP_068909371.1 murein transglycosylase -
DQN80_RS03230 747207..747524 + 318 WP_068439659.1 trp operon repressor -
DQN80_RS03235 747610..748146 - 537 WP_068439155.1 inosine/xanthosine triphosphatase -
DQN80_RS03240 748199..748843 + 645 WP_068439157.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB -
DQN80_RS03245 748890..749822 - 933 WP_068909373.1 MDR efflux pump AcrAB transcriptional activator RobA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10763.42 Da        Isoelectric Point: 10.6271

>T292538 WP_068909369.1 NZ_LS483422:744331-744612 [Providencia heimbachae]
VIKSFKHKGIERFFKTGITSGIQVKHITKLRIQLTALNTAKKPNDMSAPSWKLHQLKGADLQNHWSISVNGNWRLTFKFE
GENVILVDYQDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9991.52 Da        Isoelectric Point: 7.3174

>AT292538 WP_068439151.1 NZ_LS483422:744623-744901 [Providencia heimbachae]
MSKMHNPEHPGLVLREYLDGISVTDAAKALGVTRATLSRILNGNSGISADMALRLEIALGTSAEMWVNMQAQYELWQAAQ
GTRPVVKAIFAH

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JQL3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JQM8

References