Detailed information of TA system TA292517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 2660793..2662030
• Replicon: chromosome
• Accession: NZ_LS483410
• Organism: Legionella pneumophila strain NCTC11404

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: DQN67_RS12090
• Protein ID: WP_027224428.1
• Coordinates: 2661098..2662030 (+)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: DQN67_RS12085
• Protein ID: WP_027224429.1
• Coordinates: 2660793..2661101 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQN67_RS12060	2656479..2656676	-	198	WP_014842401.1	hypothetical protein	-
DQN67_RS12065	2656696..2657922	-	1227	WP_027224432.1	MFS transporter	-
DQN67_RS12070	2658557..2659030	+	474	WP_027224431.1	hypothetical protein	-
DQN67_RS12075	2659209..2660126	+	918	WP_027224430.1	LysR family transcriptional regulator	-
DQN67_RS12080	2660569..2660796	+	228	WP_013101792.1	helix-turn-helix transcriptional regulator	-
DQN67_RS12085	2660793..2661101	+	309	WP_027224429.1	HipA N-terminal domain-containing protein	Antitoxin
DQN67_RS12090	2661098..2662030	+	933	WP_027224428.1	HipA domain-containing protein	Toxin
DQN67_RS12095	2662159..2664726	+	2568	WP_027224427.1	magnesium-translocating P-type ATPase	-
DQN67_RS12100	2664761..2665705	+	945	WP_027224426.1	flippase-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (53-279)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35780.41 Da
• Isoelectric Point: 9.5904

>T292517 WP_027224428.1 NZ_LS483410:2661098-2662030 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF

Nucleotide

• Length: 933 bp

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11586.38 Da
• Isoelectric Point: 4.5859

>AT292517 WP_027224429.1 NZ_LS483410:2660793-2661101 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Nucleotide

• Length: 309 bp