Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2889637..2890292 Replicon chromosome
Accession NZ_LS483398
Organism Bordetella pertussis strain NCTC10910

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag DQO07_RS14010 Protein ID WP_047122780.1
Coordinates 2890041..2890292 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag DQO07_RS14005 Protein ID WP_003809516.1
Coordinates 2889637..2890038 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO07_RS13975 2884820..2885842 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
DQO07_RS13980 2885979..2887016 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
DQO07_RS13985 2887036..2888226 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
DQO07_RS13990 2888229..2888744 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DQO07_RS13995 2888894..2889373 - 480 WP_010930405.1 disulfide bond formation protein B -
DQO07_RS14000 2889381..2889617 - 237 WP_010930404.1 membrane protein -
DQO07_RS14005 2889637..2890038 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
DQO07_RS14010 2890041..2890292 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
DQO07_RS14015 2890347..2891228 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
DQO07_RS14020 2891453..2891899 + 447 WP_003819827.1 GFA family protein -
DQO07_RS14025 2891984..2893048 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
DQO07_RS14030 2893185..2893766 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
DQO07_RS14035 2894001..2895131 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292498 WP_047122780.1 NZ_LS483398:c2890292-2890041 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292498 WP_003809516.1 NZ_LS483398:c2890038-2889637 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References