Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1350210..1350879 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag DQM65_RS06965 Protein ID WP_015701504.1
Coordinates 1350210..1350593 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag DQM65_RS06970 Protein ID WP_005651224.1
Coordinates 1350577..1350879 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS06930 1346970..1347293 + 324 WP_059358265.1 DUF2190 family protein -
DQM65_RS06935 1347274..1347585 + 312 WP_015701509.1 hypothetical protein -
DQM65_RS06940 1347588..1348118 + 531 WP_015701508.1 phage tail protein -
DQM65_RS06945 1348127..1348537 + 411 WP_111691593.1 phage tail protein -
DQM65_RS06950 1348540..1349190 + 651 WP_038440702.1 hypothetical protein -
DQM65_RS06955 1349465..1349872 + 408 WP_038440705.1 hypothetical protein -
DQM65_RS06960 1349917..1350141 + 225 WP_038440708.1 DUF4035 domain-containing protein -
DQM65_RS06965 1350210..1350593 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM65_RS06970 1350577..1350879 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
DQM65_RS06975 1350895..1351131 + 237 WP_101494098.1 hypothetical protein -
DQM65_RS06980 1351238..1351369 + 132 WP_111691594.1 DUF4035 domain-containing protein -
DQM65_RS06985 1351433..1351681 + 249 WP_015701502.1 hypothetical protein -
DQM65_RS06990 1351760..1355101 + 3342 WP_111691595.1 tape measure protein -
DQM65_RS06995 1355110..1355445 + 336 WP_111691596.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1283429..1415987 132558
- inside Prophage - - 1286941..1415987 129046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T292488 WP_015701504.1 NZ_LS483392:1350210-1350593 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT292488 WP_005651224.1 NZ_LS483392:1350577-1350879 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References