Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1567818..1568330 Replicon chromosome
Accession NZ_LS483390
Organism Streptococcus pneumoniae strain NCTC13276

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag DQM93_RS08210 Protein ID WP_000924721.1
Coordinates 1567818..1568072 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag DQM93_RS08215 Protein ID WP_000388572.1
Coordinates 1568076..1568330 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM93_RS08195 1564919..1565233 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
DQM93_RS08200 1565258..1565884 - 627 WP_000775044.1 guanylate kinase -
DQM93_RS08205 1566014..1567627 - 1614 WP_000404940.1 ribonuclease Y -
DQM93_RS08210 1567818..1568072 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
DQM93_RS08215 1568076..1568330 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQM93_RS08220 1568568..1569665 - 1098 WP_000156355.1 nucleotidyltransferase -
DQM93_RS08225 1569675..1570421 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
DQM93_RS08230 1570524..1570877 - 354 WP_001003001.1 ribosome silencing factor -
DQM93_RS08235 1570890..1571390 - 501 WP_000844717.1 cysteine hydrolase -
DQM93_RS08240 1571391..1571984 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
DQM93_RS08245 1571984..1572613 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
DQM93_RS08250 1572665..1572976 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T292478 WP_000924721.1 NZ_LS483390:c1568072-1567818 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT292478 WP_000388572.1 NZ_LS483390:c1568330-1568076 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References