Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2511044..2511228 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag DQM91_RS13375 Protein ID WP_000482650.1
Coordinates 2511121..2511228 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2511044..2511104 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS13350 2506574..2506741 - 168 WP_001790576.1 hypothetical protein -
DQM91_RS13360 2506972..2508705 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
DQM91_RS13365 2508730..2510493 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2511044..2511104 + 61 - - Antitoxin
DQM91_RS13375 2511121..2511228 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
DQM91_RS13380 2511362..2511748 - 387 WP_000779358.1 flippase GtxA -
DQM91_RS13385 2512016..2513158 + 1143 WP_001176863.1 glycerate kinase -
DQM91_RS13390 2513218..2513877 + 660 WP_000831298.1 membrane protein -
DQM91_RS13395 2514059..2515270 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
DQM91_RS13400 2515393..2515866 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T292442 WP_000482650.1 NZ_LS483365:c2511228-2511121 [Staphylococcus aureus subsp. aureus NCTC 8325]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT292442 NZ_LS483365:2511044-2511104 [Staphylococcus aureus subsp. aureus NCTC 8325]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References