Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2485692..2486209 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DQM91_RS13215 Protein ID WP_000113262.1
Coordinates 2485692..2485958 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQM91_RS13220 Protein ID WP_000584499.1
Coordinates 2485958..2486209 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS13185 2481118..2481654 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
DQM91_RS13190 2481887..2482711 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DQM91_RS13195 2482928..2483110 - 183 WP_000230294.1 hypothetical protein -
DQM91_RS13200 2483194..2483661 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DQM91_RS13205 2483847..2485397 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQM91_RS13210 2485586..2485657 - 72 Protein_2442 hypothetical protein -
DQM91_RS13215 2485692..2485958 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DQM91_RS13220 2485958..2486209 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQM91_RS13225 2486374..2486475 - 102 WP_001791744.1 hypothetical protein -
DQM91_RS13230 2486482..2487081 - 600 WP_000162813.1 DsbA family protein -
DQM91_RS13235 2487100..2487462 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQM91_RS13240 2487717..2488967 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
DQM91_RS13245 2489064..2489795 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DQM91_RS13250 2489792..2490511 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T292441 WP_000113262.1 NZ_LS483365:c2485958-2485692 [Staphylococcus aureus subsp. aureus NCTC 8325]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292441 WP_000584499.1 NZ_LS483365:c2486209-2485958 [Staphylococcus aureus subsp. aureus NCTC 8325]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References