Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2220574..2220837 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DQM91_RS11790 Protein ID WP_001802298.1
Coordinates 2220733..2220837 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2220574..2220738 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS11770 2216814..2217479 - 666 WP_001024094.1 SDR family oxidoreductase -
DQM91_RS11775 2217631..2217951 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DQM91_RS11780 2217953..2218933 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
DQM91_RS11785 2219199..2220290 + 1092 WP_000495671.1 lytic regulatory protein -
- 2220574..2220738 + 165 - - Antitoxin
DQM91_RS11790 2220733..2220837 - 105 WP_001802298.1 hypothetical protein Toxin
DQM91_RS14985 2220998..2221481 - 484 Protein_2176 recombinase family protein -
DQM91_RS11800 2221524..2222660 - 1137 WP_000115562.1 SAP domain-containing protein -
DQM91_RS11805 2222949..2223041 + 93 WP_001790138.1 hypothetical protein -
DQM91_RS11810 2223746..2224603 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
DQM91_RS11815 2224671..2225453 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T292439 WP_001802298.1 NZ_LS483365:c2220837-2220733 [Staphylococcus aureus subsp. aureus NCTC 8325]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

Antitoxin


Download         Length: 165 bp

>AT292439 NZ_LS483365:2220574-2220738 [Staphylococcus aureus subsp. aureus NCTC 8325]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References