Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2197572..2197835 Replicon chromosome
Accession NZ_LS483350
Organism Staphylococcus aureus strain NCTC11940

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DQM92_RS11435 Protein ID WP_001802298.1
Coordinates 2197731..2197835 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2197572..2197736 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM92_RS11415 2193755..2194420 - 666 WP_001024094.1 SDR family oxidoreductase -
DQM92_RS11420 2194572..2194892 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DQM92_RS11425 2194894..2195874 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
DQM92_RS11430 2196140..2197231 + 1092 WP_000495671.1 lytic regulatory protein -
- 2197572..2197736 + 165 - - Antitoxin
DQM92_RS11435 2197731..2197835 - 105 WP_001802298.1 hypothetical protein Toxin
DQM92_RS14725 2197996..2198479 - 484 Protein_2105 recombinase family protein -
DQM92_RS11445 2198522..2199394 - 873 Protein_2106 DNA-binding protein -
DQM92_RS11450 2199446..2200618 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
DQM92_RS11460 2200721..2200990 - 270 Protein_2108 SAP domain-containing protein -
DQM92_RS11465 2201279..2201371 + 93 WP_001790138.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2199446..2200618 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T292406 WP_001802298.1 NZ_LS483350:c2197835-2197731 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

Antitoxin


Download         Length: 165 bp

>AT292406 NZ_LS483350:2197572-2197736 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References