Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2551141..2551640 Replicon chromosome
Accession NZ_LS483324
Organism Staphylococcus aureus strain NCTC10344

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag DQL79_RS13370 Protein ID WP_000074044.1
Coordinates 2551141..2551383 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag DQL79_RS13375 Protein ID WP_000587618.1
Coordinates 2551383..2551640 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL79_RS13350 2546446..2547633 - 1188 WP_000026189.1 MFS transporter -
DQL79_RS13355 2548029..2548805 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
DQL79_RS13360 2548798..2549460 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
DQL79_RS13365 2549708..2550784 - 1077 WP_001836950.1 M42 family metallopeptidase -
DQL79_RS13370 2551141..2551383 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
DQL79_RS13375 2551383..2551640 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL79_RS13385 2551999..2552454 + 456 WP_000732082.1 DUF1307 domain-containing protein -
DQL79_RS13390 2552622..2554199 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
DQL79_RS13395 2554394..2555143 + 750 WP_111763593.1 hypothetical protein -
DQL79_RS13400 2555374..2556567 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T292372 WP_000074044.1 NZ_LS483324:c2551383-2551141 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT292372 WP_000587618.1 NZ_LS483324:c2551640-2551383 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References