Detailed information of TA system TA292364

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2047901..2048208
• Replicon: chromosome
• Accession: NZ_LS483324
• Organism: Staphylococcus aureus strain NCTC10344

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DQL79_RS10530
• Protein ID: WP_072353918.1
• Coordinates: 2048032..2048208 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2047901..2048040 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL79_RS10475	2043467..2043646	+	180	WP_000669789.1	hypothetical protein	-
DQL79_RS10485	2043957..2044217	+	261	WP_001791826.1	hypothetical protein	-
DQL79_RS10490	2044270..2044620	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
DQL79_RS10495	2045130..2045465	-	336	Protein_1939	SH3 domain-containing protein	-
DQL79_RS10510	2046117..2046608	-	492	WP_000920041.1	staphylokinase	-
DQL79_RS10515	2046799..2047554	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL79_RS10520	2047566..2047820	-	255	WP_000611512.1	phage holin	-
DQL79_RS10525	2047872..2047979	+	108	WP_001791821.1	hypothetical protein	-
-	2047901..2048040	+	140	NuclAT_0	-	Antitoxin
-	2047901..2048040	+	140	NuclAT_0	-	Antitoxin
-	2047901..2048040	+	140	NuclAT_0	-	Antitoxin
-	2047901..2048040	+	140	NuclAT_0	-	Antitoxin
DQL79_RS10530	2048032..2048208	-	177	WP_072353918.1	putative holin-like toxin	Toxin
DQL79_RS10535	2048351..2048725	-	375	WP_000340977.1	hypothetical protein	-
DQL79_RS10540	2048781..2049068	-	288	WP_001262620.1	hypothetical protein	-
DQL79_RS10545	2049114..2049266	-	153	WP_001000058.1	hypothetical protein	-
DQL79_RS10550	2049259..2053041	-	3783	WP_001836550.1	phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2044270..2112802	68532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T292364 WP_072353918.1 NZ_LS483324:c2048208-2048032 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292364 NZ_LS483324:2047901-2048040 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin