292340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478897..2479414 Replicon chromosome
Accession NZ_LS483317
Organism Staphylococcus aureus strain NCTC5663

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag DQL75_RS12775 Protein ID WP_000113263.1
Coordinates 2478897..2479163 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL75_RS12780 Protein ID WP_000584499.1
Coordinates 2479163..2479414 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL75_RS12745 2474044..2474580 - 537 WP_111762830.1 GNAT family N-acetyltransferase -
DQL75_RS12755 2475107..2475931 - 825 WP_000594633.1 formate/nitrite transporter family protein -
DQL75_RS12760 2476134..2476316 - 183 WP_111762648.1 hypothetical protein -
DQL75_RS12765 2476403..2476870 - 468 WP_111762649.1 SRPBCC domain-containing protein -
DQL75_RS12770 2477056..2478603 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL75_RS12775 2478897..2479163 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
DQL75_RS12780 2479163..2479414 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL75_RS12785 2479680..2480279 - 600 WP_000162810.1 DsbA family protein -
DQL75_RS12790 2480298..2480660 - 363 WP_000819844.1 DUF4467 domain-containing protein -
DQL75_RS12795 2480915..2482164 + 1250 Protein_2374 FemA/FemB family glycyltransferase FmhA -
DQL75_RS12800 2482261..2482992 - 732 WP_000615462.1 amino acid ABC transporter ATP-binding protein -
DQL75_RS12805 2482989..2483708 - 720 WP_111762650.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T292340 WP_000113263.1 NZ_LS483317:c2479163-2478897 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292340 WP_000584499.1 NZ_LS483317:c2479414-2479163 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References