Detailed information of TA system TA292332

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 368372..368679
• Replicon: chromosome
• Accession: NZ_LS483317
• Organism: Staphylococcus aureus strain NCTC5663

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: DQL75_RS01780
• Protein ID: WP_072357969.1
• Coordinates: 368372..368548 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	368540..368679 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL75_RS01760	363607..367392	+	3786	WP_111761862.1	hypothetical protein	-
DQL75_RS01765	367382..367534	+	153	WP_031867842.1	hypothetical protein	-
DQL75_RS01770	367581..367868	+	288	WP_001040261.1	hypothetical protein	-
DQL75_RS01775	367926..368222	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DQL75_RS01780	368372..368548	+	177	WP_072357969.1	putative holin-like toxin	Toxin
-	368540..368679	-	140	NuclAT_0	-	Antitoxin
-	368540..368679	-	140	NuclAT_0	-	Antitoxin
-	368540..368679	-	140	NuclAT_0	-	Antitoxin
-	368540..368679	-	140	NuclAT_0	-	Antitoxin
DQL75_RS01785	368601..368708	-	108	WP_047551145.1	hypothetical protein	-
DQL75_RS01790	368760..369014	+	255	WP_045178738.1	phage holin	-
DQL75_RS01795	369026..369781	+	756	WP_111761863.1	CHAP domain-containing protein	-
DQL75_RS01800	370220..371155	+	936	WP_111761864.1	bi-component leukocidin LukPQ subunit P	-
DQL75_RS01805	371157..372137	+	981	WP_086037611.1	bi-component leukocidin LukPQ subunit Q	-
DQL75_RS01810	372578..372922	+	345	WP_106096712.1	complement inhibitor SCIN family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	330594..372922	42328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T292332 WP_072357969.1 NZ_LS483317:368372-368548 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292332 NZ_LS483317:c368679-368540 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACACGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin