Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2491738..2492237 Replicon chromosome
Accession NZ_LS483314
Organism Staphylococcus aureus strain NCTC3761

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag DQL90_RS12980 Protein ID WP_000074044.1
Coordinates 2491738..2491980 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag DQL90_RS12985 Protein ID WP_000587618.1
Coordinates 2491980..2492237 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL90_RS12960 2487043..2488230 - 1188 WP_111688686.1 MFS transporter -
DQL90_RS12965 2488626..2489402 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
DQL90_RS12970 2489395..2490057 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
DQL90_RS12975 2490305..2491381 - 1077 WP_001076672.1 M42 family metallopeptidase -
DQL90_RS12980 2491738..2491980 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
DQL90_RS12985 2491980..2492237 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL90_RS12995 2492596..2493051 + 456 WP_000732082.1 DUF1307 domain-containing protein -
DQL90_RS13000 2493219..2494796 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
DQL90_RS13005 2494991..2495740 + 750 WP_000072459.1 hypothetical protein -
DQL90_RS13010 2495971..2497164 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T292314 WP_000074044.1 NZ_LS483314:c2491980-2491738 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT292314 WP_000587618.1 NZ_LS483314:c2492237-2491980 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References