Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2569052..2569575 Replicon chromosome
Accession NZ_LS483311
Organism Staphylococcus aureus strain NCTC6136

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag DQL83_RS13625 Protein ID WP_000074043.1
Coordinates 2569052..2569318 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag DQL83_RS13630 Protein ID WP_000587618.1
Coordinates 2569318..2569575 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL83_RS13605 2564358..2565545 - 1188 WP_000026194.1 MFS transporter -
DQL83_RS13610 2565941..2566717 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
DQL83_RS13615 2566710..2567372 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
DQL83_RS13620 2567620..2568696 - 1077 WP_001076673.1 M42 family metallopeptidase -
DQL83_RS13625 2569052..2569318 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
DQL83_RS13630 2569318..2569575 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL83_RS13640 2569935..2570390 + 456 WP_000732076.1 DUF1307 domain-containing protein -
DQL83_RS13645 2570558..2572135 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
DQL83_RS13650 2572330..2573079 + 750 WP_000072466.1 hypothetical protein -
DQL83_RS13655 2573310..2574503 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T292301 WP_000074043.1 NZ_LS483311:c2569318-2569052 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT292301 WP_000587618.1 NZ_LS483311:c2569575-2569318 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References