Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2512211..2512728 Replicon chromosome
Accession NZ_LS483311
Organism Staphylococcus aureus strain NCTC6136

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DQL83_RS13300 Protein ID WP_000113262.1
Coordinates 2512211..2512477 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL83_RS13305 Protein ID WP_000584499.1
Coordinates 2512477..2512728 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL83_RS13275 2507636..2508172 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DQL83_RS13280 2508405..2509229 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DQL83_RS13285 2509446..2509628 - 183 WP_000230294.1 hypothetical protein -
DQL83_RS13290 2509712..2510179 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DQL83_RS13295 2510365..2511915 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL83_RS13300 2512211..2512477 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DQL83_RS13305 2512477..2512728 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL83_RS13310 2512893..2512994 - 102 WP_031774922.1 hypothetical protein -
DQL83_RS13315 2513001..2513600 - 600 WP_000162813.1 DsbA family protein -
DQL83_RS13320 2513619..2513981 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL83_RS13325 2514236..2515486 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
DQL83_RS13330 2515583..2516314 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DQL83_RS13335 2516311..2517030 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T292299 WP_000113262.1 NZ_LS483311:c2512477-2512211 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292299 WP_000584499.1 NZ_LS483311:c2512728-2512477 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References