Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2076419..2076718 Replicon chromosome
Accession NZ_LS483311
Organism Staphylococcus aureus strain NCTC6136

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DQL83_RS10870 Protein ID WP_011447039.1
Coordinates 2076542..2076718 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2076419..2076474 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL83_RS10825 2071750..2072010 + 261 WP_001791826.1 hypothetical protein -
DQL83_RS10830 2072063..2072413 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DQL83_RS10835 2073098..2073547 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DQL83_RS10840 2073642..2073977 - 336 Protein_2005 SH3 domain-containing protein -
DQL83_RS10850 2074627..2075118 - 492 WP_000920037.1 staphylokinase -
DQL83_RS10855 2075309..2076064 - 756 WP_000861038.1 CHAP domain-containing protein -
DQL83_RS10860 2076076..2076330 - 255 WP_000611512.1 phage holin -
DQL83_RS10865 2076382..2076489 + 108 WP_001791821.1 hypothetical protein -
- 2076411..2076550 + 140 NuclAT_0 - -
- 2076411..2076550 + 140 NuclAT_0 - -
- 2076411..2076550 + 140 NuclAT_0 - -
- 2076411..2076550 + 140 NuclAT_0 - -
- 2076419..2076474 + 56 - - Antitoxin
DQL83_RS10870 2076542..2076718 - 177 WP_011447039.1 putative holin-like toxin Toxin
DQL83_RS10875 2076868..2077164 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DQL83_RS10880 2077222..2077509 - 288 WP_001040261.1 hypothetical protein -
DQL83_RS10885 2077556..2077708 - 153 WP_001153681.1 hypothetical protein -
DQL83_RS10890 2077698..2081483 - 3786 WP_000582186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2072063..2128740 56677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T292293 WP_011447039.1 NZ_LS483311:c2076718-2076542 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT292293 NZ_LS483311:2076419-2076474 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References