Detailed information of TA system TA292292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2076411..2076718
• Replicon: chromosome
• Accession: NZ_LS483311
• Organism: Staphylococcus aureus strain NCTC6136

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DQL83_RS10870
• Protein ID: WP_011447039.1
• Coordinates: 2076542..2076718 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2076411..2076550 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL83_RS10825	2071750..2072010	+	261	WP_001791826.1	hypothetical protein	-
DQL83_RS10830	2072063..2072413	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DQL83_RS10835	2073098..2073547	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DQL83_RS10840	2073642..2073977	-	336	Protein_2005	SH3 domain-containing protein	-
DQL83_RS10850	2074627..2075118	-	492	WP_000920037.1	staphylokinase	-
DQL83_RS10855	2075309..2076064	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL83_RS10860	2076076..2076330	-	255	WP_000611512.1	phage holin	-
DQL83_RS10865	2076382..2076489	+	108	WP_001791821.1	hypothetical protein	-
-	2076411..2076550	+	140	NuclAT_0	-	Antitoxin
-	2076411..2076550	+	140	NuclAT_0	-	Antitoxin
-	2076411..2076550	+	140	NuclAT_0	-	Antitoxin
-	2076411..2076550	+	140	NuclAT_0	-	Antitoxin
DQL83_RS10870	2076542..2076718	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DQL83_RS10875	2076868..2077164	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DQL83_RS10880	2077222..2077509	-	288	WP_001040261.1	hypothetical protein	-
DQL83_RS10885	2077556..2077708	-	153	WP_001153681.1	hypothetical protein	-
DQL83_RS10890	2077698..2081483	-	3786	WP_000582186.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2072063..2128740	56677

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T292292 WP_011447039.1 NZ_LS483311:c2076718-2076542 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292292 NZ_LS483311:2076411-2076550 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin