Detailed information of TA system TA292286

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 319171..319750
• Replicon: chromosome
• Accession: NZ_LS483311
• Organism: Staphylococcus aureus strain NCTC6136

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DQL83_RS01495
• Protein ID: WP_001025401.1
• Coordinates: 319171..319416 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	319385..319750 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL83_RS01450	315189..315803	+	615	WP_000191466.1	hypothetical protein	-
DQL83_RS01455	315800..315946	-	147	WP_074370993.1	hypothetical protein	-
DQL83_RS01460	316176..316760	-	585	WP_000825948.1	hypothetical protein	-
DQL83_RS01465	316778..317239	-	462	WP_000525004.1	hypothetical protein	-
DQL83_RS01470	317252..317566	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DQL83_RS01475	317718..317954	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DQL83_RS01480	317968..318744	+	777	WP_111724364.1	Rha family transcriptional regulator	-
DQL83_RS01485	318773..318916	+	144	WP_000939498.1	hypothetical protein	-
DQL83_RS01490	318906..319115	-	210	WP_000642492.1	hypothetical protein	-
DQL83_RS01495	319171..319416	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DQL83_RS01500	319385..319750	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DQL83_RS01505	319805..320020	+	216	WP_001097552.1	hypothetical protein	-
DQL83_RS01510	320045..320308	+	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
DQL83_RS01515	320321..320482	+	162	WP_001285963.1	DUF1270 family protein	-
DQL83_RS01520	320561..320884	+	324	WP_000174994.1	hypothetical protein	-
DQL83_RS01525	320899..321261	+	363	WP_111724365.1	hypothetical protein	-
DQL83_RS01530	321258..322424	+	1167	WP_047216521.1	DUF2800 domain-containing protein	-
DQL83_RS01535	322450..323007	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	313858..358468	44610

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T292286 WP_001025401.1 NZ_LS483311:319171-319416 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT292286 NZ_LS483311:c319750-319385 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin