Detailed information of TA system TA292277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1931772..1932079
• Replicon: chromosome
• Accession: NZ_LS483310
• Organism: Staphylococcus aureus strain NCTC9752

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DQL84_RS09925
• Protein ID: WP_072353918.1
• Coordinates: 1931903..1932079 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1931772..1931911 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL84_RS09870	1927338..1927517	+	180	WP_000669789.1	hypothetical protein	-
DQL84_RS09880	1927828..1928088	+	261	WP_001791826.1	hypothetical protein	-
DQL84_RS09885	1928141..1928491	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
DQL84_RS09890	1929001..1929336	-	336	Protein_1826	SH3 domain-containing protein	-
DQL84_RS09905	1929988..1930479	-	492	WP_000920041.1	staphylokinase	-
DQL84_RS09910	1930670..1931425	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL84_RS09915	1931437..1931691	-	255	WP_000611512.1	phage holin	-
DQL84_RS09920	1931743..1931850	+	108	WP_001791821.1	hypothetical protein	-
-	1931772..1931911	+	140	NuclAT_0	-	Antitoxin
-	1931772..1931911	+	140	NuclAT_0	-	Antitoxin
-	1931772..1931911	+	140	NuclAT_0	-	Antitoxin
-	1931772..1931911	+	140	NuclAT_0	-	Antitoxin
DQL84_RS09925	1931903..1932079	-	177	WP_072353918.1	putative holin-like toxin	Toxin
DQL84_RS09930	1932222..1932596	-	375	WP_000340977.1	hypothetical protein	-
DQL84_RS09935	1932652..1932939	-	288	WP_001262620.1	hypothetical protein	-
DQL84_RS09940	1932985..1933137	-	153	WP_001000058.1	hypothetical protein	-
DQL84_RS09945	1933130..1936912	-	3783	WP_001836550.1	phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1928141..1996468	68327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T292277 WP_072353918.1 NZ_LS483310:c1932079-1931903 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292277 NZ_LS483310:1931772-1931911 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin