Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2586676..2587193 Replicon chromosome
Accession NZ_LS483309
Organism Staphylococcus aureus strain NCTC9944

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DQL96_RS13680 Protein ID WP_000113262.1
Coordinates 2586676..2586942 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL96_RS13685 Protein ID WP_000584499.1
Coordinates 2586942..2587193 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL96_RS13650 2582102..2582638 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DQL96_RS13655 2582871..2583695 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DQL96_RS13660 2583912..2584094 - 183 WP_000230294.1 hypothetical protein -
DQL96_RS13665 2584178..2584645 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DQL96_RS13670 2584831..2586381 - 1551 WP_016187839.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL96_RS13675 2586570..2586641 - 72 Protein_2532 hypothetical protein -
DQL96_RS13680 2586676..2586942 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DQL96_RS13685 2586942..2587193 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL96_RS13690 2587358..2587459 - 102 WP_001791744.1 hypothetical protein -
DQL96_RS13695 2587466..2588065 - 600 WP_000162813.1 DsbA family protein -
DQL96_RS13700 2588084..2588446 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL96_RS13705 2588700..2589950 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
DQL96_RS13710 2590047..2590778 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DQL96_RS13715 2590775..2591494 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T292272 WP_000113262.1 NZ_LS483309:c2586942-2586676 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292272 WP_000584499.1 NZ_LS483309:c2587193-2586942 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References