Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2135842..2136141 Replicon chromosome
Accession NZ_LS483309
Organism Staphylococcus aureus strain NCTC9944

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DQL96_RS11135 Protein ID WP_011447039.1
Coordinates 2135965..2136141 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2135842..2135897 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL96_RS11090 2131669..2131848 + 180 Protein_2046 sphingomyelin phosphodiesterase -
DQL96_RS11095 2132238..2132417 + 180 WP_000669789.1 hypothetical protein -
DQL96_RS11105 2132728..2132988 + 261 WP_001791826.1 hypothetical protein -
DQL96_RS11110 2133041..2133391 - 351 WP_000702262.1 complement inhibitor SCIN-A -
DQL96_RS11115 2134050..2134541 - 492 WP_000919350.1 staphylokinase -
DQL96_RS11120 2134732..2135487 - 756 WP_000861038.1 CHAP domain-containing protein -
DQL96_RS11125 2135499..2135753 - 255 WP_000611512.1 phage holin -
DQL96_RS11130 2135805..2135912 + 108 WP_001791821.1 hypothetical protein -
- 2135834..2135973 + 140 NuclAT_0 - -
- 2135834..2135973 + 140 NuclAT_0 - -
- 2135834..2135973 + 140 NuclAT_0 - -
- 2135834..2135973 + 140 NuclAT_0 - -
- 2135842..2135897 + 56 - - Antitoxin
DQL96_RS11135 2135965..2136141 - 177 WP_011447039.1 putative holin-like toxin Toxin
DQL96_RS11140 2136291..2136587 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DQL96_RS11145 2136645..2136932 - 288 WP_001040261.1 hypothetical protein -
DQL96_RS11150 2136979..2137131 - 153 WP_001153681.1 hypothetical protein -
DQL96_RS11155 2137121..2140906 - 3786 WP_053015728.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 2133041..2192330 59289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T292263 WP_011447039.1 NZ_LS483309:c2136141-2135965 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT292263 NZ_LS483309:2135842-2135897 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References