292257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2480216..2480739 Replicon chromosome
Accession NZ_LS483308
Organism Staphylococcus aureus strain NCTC13137

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag DQL85_RS12910 Protein ID WP_000074045.1
Coordinates 2480216..2480482 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag DQL85_RS12915 Protein ID WP_000587619.1
Coordinates 2480482..2480739 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL85_RS12890 2475525..2476712 - 1188 WP_000026189.1 MFS transporter -
DQL85_RS12895 2477106..2477882 - 777 WP_006191020.1 iron export ABC transporter permease subunit FetB -
DQL85_RS12900 2477875..2478537 - 663 WP_006191024.1 ATP-binding cassette domain-containing protein -
DQL85_RS12905 2478785..2479861 - 1077 WP_001076673.1 M42 family metallopeptidase -
DQL85_RS12910 2480216..2480482 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
DQL85_RS12915 2480482..2480739 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL85_RS12925 2481099..2481554 + 456 WP_000732082.1 DUF1307 domain-containing protein -
DQL85_RS12930 2481722..2483299 - 1578 WP_006191029.1 FMN-binding glutamate synthase family protein -
DQL85_RS12935 2483494..2484243 + 750 WP_006191031.1 hypothetical protein -
DQL85_RS12940 2484467..2485660 - 1194 WP_006191034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T292257 WP_000074045.1 NZ_LS483308:c2480482-2480216 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT292257 WP_000587619.1 NZ_LS483308:c2480739-2480482 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References