Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2423516..2424033 Replicon chromosome
Accession NZ_LS483308
Organism Staphylococcus aureus strain NCTC13137

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DQL85_RS12595 Protein ID WP_000113262.1
Coordinates 2423516..2423782 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL85_RS12600 Protein ID WP_000584499.1
Coordinates 2423782..2424033 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL85_RS12565 2418942..2419478 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DQL85_RS12570 2419711..2420535 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DQL85_RS12575 2420752..2420934 - 183 WP_000230294.1 hypothetical protein -
DQL85_RS12580 2421018..2421485 - 468 WP_000153346.1 SRPBCC domain-containing protein -
DQL85_RS12585 2421671..2423221 - 1551 WP_111743913.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL85_RS12590 2423410..2423481 - 72 Protein_2330 hypothetical protein -
DQL85_RS12595 2423516..2423782 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DQL85_RS12600 2423782..2424033 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL85_RS12605 2424198..2424299 - 102 Protein_2333 hypothetical protein -
DQL85_RS12610 2424306..2424905 - 600 WP_000162810.1 DsbA family protein -
DQL85_RS12615 2424924..2425286 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL85_RS12620 2425541..2426791 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
DQL85_RS12625 2426888..2427619 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DQL85_RS12630 2427616..2428335 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T292255 WP_000113262.1 NZ_LS483308:c2423782-2423516 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292255 WP_000584499.1 NZ_LS483308:c2424033-2423782 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References