Detailed information of TA system TA292247

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1987878..1988185
• Replicon: chromosome
• Accession: NZ_LS483308
• Organism: Staphylococcus aureus strain NCTC13137

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DQL85_RS10175
• Protein ID: WP_011447039.1
• Coordinates: 1988009..1988185 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1987878..1988017 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL85_RS10115	1983443..1983622	+	180	WP_000669789.1	hypothetical protein	-
DQL85_RS10125	1983933..1984193	+	261	WP_001791826.1	hypothetical protein	-
DQL85_RS10130	1984246..1984596	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DQL85_RS10135	1985108..1985443	-	336	Protein_1867	SH3 domain-containing protein	-
DQL85_RS10155	1986094..1986585	-	492	WP_000920038.1	staphylokinase	-
DQL85_RS10160	1986776..1987531	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL85_RS10165	1987543..1987797	-	255	WP_000611512.1	phage holin	-
DQL85_RS10170	1987849..1987956	+	108	WP_031762631.1	hypothetical protein	-
-	1987878..1988017	+	140	NuclAT_0	-	Antitoxin
-	1987878..1988017	+	140	NuclAT_0	-	Antitoxin
-	1987878..1988017	+	140	NuclAT_0	-	Antitoxin
-	1987878..1988017	+	140	NuclAT_0	-	Antitoxin
DQL85_RS10175	1988009..1988185	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DQL85_RS10180	1988388..1989161	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
DQL85_RS10185	1989582..1989956	-	375	WP_000340977.1	hypothetical protein	-
DQL85_RS10190	1990012..1990299	-	288	WP_001040255.1	hypothetical protein	-
DQL85_RS10195	1990346..1990498	-	153	WP_111743871.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see / hlb / hlb / groEL	1984246..2040333	56087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T292247 WP_011447039.1 NZ_LS483308:c1988185-1988009 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292247 NZ_LS483308:1987878-1988017 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin