Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2441204..2441388 Replicon chromosome
Accession NC_020566
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAI5S5_RS12350 Protein ID WP_000482652.1
Coordinates 2441281..2441388 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2441204..2441264 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI5S5_RS12325 2436659..2436826 - 168 Protein_2327 hypothetical protein -
SAI5S5_RS12335 2437057..2438790 - 1734 WP_000486483.1 ABC transporter ATP-binding protein/permease -
SAI5S5_RS12340 2438815..2440578 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2441204..2441264 + 61 - - Antitoxin
SAI5S5_RS12350 2441281..2441388 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAI5S5_RS12355 2441522..2441908 - 387 WP_000779360.1 flippase GtxA -
SAI5S5_RS12360 2442176..2443318 + 1143 WP_001176863.1 glycerate kinase -
SAI5S5_RS12365 2443378..2444037 + 660 WP_000831302.1 hypothetical protein -
SAI5S5_RS12370 2444219..2445430 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAI5S5_RS12375 2445553..2446026 - 474 WP_015445934.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T29224 WP_000482652.1 NC_020566:c2441388-2441281 [Staphylococcus aureus subsp. aureus ST228]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T29224 NC_020566:c2441388-2441281 [Staphylococcus aureus subsp. aureus ST228]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT29224 NC_020566:2441204-2441264 [Staphylococcus aureus subsp. aureus ST228]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References