Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3614377..3614918 Replicon chromosome
Accession NZ_LS483303
Organism Escherichia coli strain NCTC9967

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag DQM88_RS18620 Protein ID WP_000615976.1
Coordinates 3614640..3614918 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag DQM88_RS18615 Protein ID WP_000729704.1
Coordinates 3614377..3614637 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM88_RS18590 3609413..3610552 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
DQM88_RS18595 3610536..3612629 + 2094 WP_089602302.1 flagellar biosynthesis protein FlhA -
DQM88_RS18600 3612734..3613012 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
DQM88_RS18605 3613005..3613361 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
DQM88_RS18610 3613418..3614191 - 774 WP_000543899.1 C40 family peptidase -
DQM88_RS18615 3614377..3614637 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
DQM88_RS18620 3614640..3614918 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
DQM88_RS18625 3615074..3615814 + 741 WP_001225679.1 murein L,D-transpeptidase -
DQM88_RS18630 3615785..3616552 - 768 WP_000333379.1 class II glutamine amidotransferase -
DQM88_RS18635 3616758..3617336 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T292235 WP_000615976.1 NZ_LS483303:3614640-3614918 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT292235 WP_000729704.1 NZ_LS483303:3614377-3614637 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References