Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2415900..2416417 | Replicon | chromosome |
| Accession | NC_020566 | ||
| Organism | Staphylococcus aureus subsp. aureus ST228 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | SAI5S5_RS12195 | Protein ID | WP_000113265.1 |
| Coordinates | 2415900..2416166 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | SAI5S5_RS12200 | Protein ID | WP_000584499.1 |
| Coordinates | 2416166..2416417 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAI5S5_RS12170 | 2411328..2411864 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| SAI5S5_RS12175 | 2412098..2412922 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| SAI5S5_RS12180 | 2413139..2413321 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| SAI5S5_RS12185 | 2413405..2413872 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| SAI5S5_RS12190 | 2414058..2415605 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| SAI5S5_RS14685 | 2415794..2415865 | - | 72 | Protein_2302 | hypothetical protein | - |
| SAI5S5_RS12195 | 2415900..2416166 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| SAI5S5_RS12200 | 2416166..2416417 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SAI5S5_RS12205 | 2416582..2416683 | - | 102 | Protein_2305 | hypothetical protein | - |
| SAI5S5_RS12210 | 2416690..2417289 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| SAI5S5_RS12215 | 2417308..2417670 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| SAI5S5_RS12220 | 2417925..2419175 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| SAI5S5_RS12225 | 2419272..2420003 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| SAI5S5_RS12230 | 2420000..2420719 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T29223 WP_000113265.1 NC_020566:c2416166-2415900 [Staphylococcus aureus subsp. aureus ST228]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T29223 NC_020566:c2416166-2415900 [Staphylococcus aureus subsp. aureus ST228]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT29223 WP_000584499.1 NC_020566:c2416417-2416166 [Staphylococcus aureus subsp. aureus ST228]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT29223 NC_020566:c2416417-2416166 [Staphylococcus aureus subsp. aureus ST228]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|