Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprA2AS/-
Location 1985064..1985363 Replicon chromosome
Accession NZ_LS483302
Organism Staphylococcus aureus strain NCTC8726

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DQL80_RS10070 Protein ID WP_011447039.1
Coordinates 1985187..1985363 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1985064..1985123 (+)

Genomic Context


DQL80_RS10010DQL80_RS10015DQL80_RS10025DQL80_RS10065------DQL80_RS10030DQL80_RS10035DQL80_RS10050DQL80_RS10055DQL80_RS10060DQL80_RS10070DQL80_RS10075DQL80_RS10080DQL80_RS10085DQL80_RS10090
Location: 1980096..1980343 (248 bp)
Type: Others
Protein ID: Protein_1847
Location: 1980665..1980844 (180 bp)
Type: Others
Protein ID: WP_000669789.1
Location: 1981155..1981415 (261 bp)
Type: Others
Protein ID: WP_001791826.1
Location: 1985027..1985134 (108 bp)
Type: Others
Protein ID: WP_031790389.1
Location: 1985056..1985195 (140 bp)
Type: Others
Protein ID: NuclAT_0
Location: 1985056..1985195 (140 bp)
Type: Others
Protein ID: NuclAT_0
Location: 1985056..1985195 (140 bp)
Type: Others
Protein ID: NuclAT_0
Location: 1985056..1985195 (140 bp)
Type: Others
Protein ID: NuclAT_0
Location: 1985064..1985123 (60 bp)
Type: Antitoxin
Protein ID: -
Location: 1981468..1981818 (351 bp)
Type: Others
Protein ID: WP_000702262.1
Location: 1982330..1982668 (339 bp)
Type: Others
Protein ID: Protein_1851
Location: 1983272..1983763 (492 bp)
Type: Others
Protein ID: WP_000920041.1
Location: 1983954..1984709 (756 bp)
Type: Others
Protein ID: WP_000861038.1
Location: 1984721..1984975 (255 bp)
Type: Others
Protein ID: WP_000611512.1
Location: 1985187..1985363 (177 bp)
Type: Toxin
Protein ID: WP_011447039.1
Location: 1985513..1985809 (297 bp)
Type: Others
Protein ID: WP_000539688.1
Location: 1985867..1986154 (288 bp)
Type: Others
Protein ID: WP_001040261.1
Location: 1986201..1986353 (153 bp)
Type: Others
Protein ID: WP_001153681.1
Location: 1986343..1990128 (3786 bp)
Type: Others
Protein ID: WP_111680465.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DQL80_RS100101980096..1980343+248Protein_1847sphingomyelin phosphodiesterase-
DQL80_RS100151980665..1980844+180WP_000669789.1hypothetical protein-
DQL80_RS100251981155..1981415+261WP_001791826.1hypothetical protein-
DQL80_RS100301981468..1981818-351WP_000702262.1complement inhibitor SCIN-A-
DQL80_RS100351982330..1982668-339Protein_1851SH3 domain-containing protein-
DQL80_RS100501983272..1983763-492WP_000920041.1staphylokinase-
DQL80_RS100551983954..1984709-756WP_000861038.1CHAP domain-containing protein-
DQL80_RS100601984721..1984975-255WP_000611512.1phage holin-
DQL80_RS100651985027..1985134+108WP_031790389.1hypothetical protein-
-1985056..1985195+140NuclAT_0--
-1985056..1985195+140NuclAT_0--
-1985056..1985195+140NuclAT_0--
-1985056..1985195+140NuclAT_0--
-1985064..1985123+60--Antitoxin
DQL80_RS100701985187..1985363-177WP_011447039.1putative holin-like toxinToxin
DQL80_RS100751985513..1985809-297WP_000539688.1DUF2951 domain-containing protein-
DQL80_RS100801985867..1986154-288WP_001040261.1hypothetical protein-
DQL80_RS100851986201..1986353-153WP_001153681.1hypothetical protein-
DQL80_RS100901986343..1990128-3786WP_111680465.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-scn / sak / hlb / groEL1981468..203196650498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T292219 WP_011447039.1 NZ_LS483302:c1985363-1985187 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp


Antitoxin


Download         Length: 60 bp

>AT292219 NZ_LS483302:1985064-1985123 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB7NS1


Antitoxin

Download structure file

References