Detailed information of TA system TA292219

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1985064..1985363
• Replicon: chromosome
• Accession: NZ_LS483302
• Organism: Staphylococcus aureus strain NCTC8726

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DQL80_RS10070
• Protein ID: WP_011447039.1
• Coordinates: 1985187..1985363 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1985064..1985123 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL80_RS10010	1980096..1980343	+	248	Protein_1847	sphingomyelin phosphodiesterase	-
DQL80_RS10015	1980665..1980844	+	180	WP_000669789.1	hypothetical protein	-
DQL80_RS10025	1981155..1981415	+	261	WP_001791826.1	hypothetical protein	-
DQL80_RS10030	1981468..1981818	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
DQL80_RS10035	1982330..1982668	-	339	Protein_1851	SH3 domain-containing protein	-
DQL80_RS10050	1983272..1983763	-	492	WP_000920041.1	staphylokinase	-
DQL80_RS10055	1983954..1984709	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL80_RS10060	1984721..1984975	-	255	WP_000611512.1	phage holin	-
DQL80_RS10065	1985027..1985134	+	108	WP_031790389.1	hypothetical protein	-
-	1985056..1985195	+	140	NuclAT_0	-	-
-	1985056..1985195	+	140	NuclAT_0	-	-
-	1985056..1985195	+	140	NuclAT_0	-	-
-	1985056..1985195	+	140	NuclAT_0	-	-
-	1985064..1985123	+	60	-	-	Antitoxin
DQL80_RS10070	1985187..1985363	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DQL80_RS10075	1985513..1985809	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DQL80_RS10080	1985867..1986154	-	288	WP_001040261.1	hypothetical protein	-
DQL80_RS10085	1986201..1986353	-	153	WP_001153681.1	hypothetical protein	-
DQL80_RS10090	1986343..1990128	-	3786	WP_111680465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1981468..2031966	50498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T292219 WP_011447039.1 NZ_LS483302:c1985363-1985187 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 60 bp

>AT292219 NZ_LS483302:1985064-1985123 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA

Structures

Toxin

• PDB: 7NS1

Antitoxin