292213

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2595971..2596488 Replicon chromosome
Accession NZ_LS483301
Organism Staphylococcus aureus strain NCTC13394

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DQL88_RS13870 Protein ID WP_000113262.1
Coordinates 2595971..2596237 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL88_RS13875 Protein ID WP_000584499.1
Coordinates 2596237..2596488 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL88_RS13840 2591397..2591933 - 537 WP_015581908.1 GNAT family N-acetyltransferase -
DQL88_RS13845 2592166..2592990 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DQL88_RS13850 2593207..2593389 - 183 WP_000230294.1 hypothetical protein -
DQL88_RS13855 2593473..2593940 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DQL88_RS13860 2594126..2595676 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL88_RS13865 2595865..2595936 - 72 Protein_2551 hypothetical protein -
DQL88_RS13870 2595971..2596237 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DQL88_RS13875 2596237..2596488 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL88_RS13880 2596653..2596754 - 102 WP_001791744.1 hypothetical protein -
DQL88_RS13885 2596761..2597360 - 600 WP_061642043.1 DsbA family protein -
DQL88_RS13890 2597379..2597741 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL88_RS13895 2597996..2599246 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
DQL88_RS13900 2599343..2600074 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DQL88_RS13905 2600071..2600790 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T292213 WP_000113262.1 NZ_LS483301:c2596237-2595971 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292213 WP_000584499.1 NZ_LS483301:c2596488-2596237 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References