Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2128703..2129010 Replicon chromosome
Accession NZ_LS483301
Organism Staphylococcus aureus strain NCTC13394

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DQL88_RS11185 Protein ID WP_011447039.1
Coordinates 2128834..2129010 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2128703..2128842 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL88_RS11130 2123740..2124090 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DQL88_RS11135 2124200..2125372 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
DQL88_RS11145 2125933..2126268 - 336 Protein_2047 SH3 domain-containing protein -
DQL88_RS11165 2126919..2127410 - 492 WP_000920038.1 staphylokinase -
DQL88_RS11170 2127601..2128356 - 756 WP_000861038.1 CHAP domain-containing protein -
DQL88_RS11175 2128368..2128622 - 255 WP_061642081.1 phage holin -
DQL88_RS11180 2128674..2128781 + 108 WP_031762631.1 hypothetical protein -
- 2128703..2128842 + 140 NuclAT_0 - Antitoxin
- 2128703..2128842 + 140 NuclAT_0 - Antitoxin
- 2128703..2128842 + 140 NuclAT_0 - Antitoxin
- 2128703..2128842 + 140 NuclAT_0 - Antitoxin
DQL88_RS11185 2128834..2129010 - 177 WP_011447039.1 putative holin-like toxin Toxin
DQL88_RS11190 2129119..2129892 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
DQL88_RS11195 2130265..2130639 - 375 WP_061642082.1 hypothetical protein -
DQL88_RS11200 2130695..2130982 - 288 WP_001262621.1 hypothetical protein -
DQL88_RS11205 2131028..2131180 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / groEL 2123740..2196582 72842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T292204 WP_011447039.1 NZ_LS483301:c2129010-2128834 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 140 bp

>AT292204 NZ_LS483301:2128703-2128842 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References