Detailed information of TA system TA292200

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1607888..1608467
• Replicon: chromosome
• Accession: NZ_LS483301
• Organism: Staphylococcus aureus strain NCTC13394

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DQL88_RS08205
• Protein ID: WP_001025401.1
• Coordinates: 1608222..1608467 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1607888..1608253 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL88_RS08165	1604631..1605188	-	558	WP_000645045.1	DUF2815 family protein	-
DQL88_RS08170	1605214..1606380	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
DQL88_RS08175	1606377..1606739	-	363	WP_000985972.1	hypothetical protein	-
DQL88_RS08180	1606754..1607077	-	324	WP_000174998.1	hypothetical protein	-
DQL88_RS08185	1607156..1607317	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
DQL88_RS08190	1607330..1607593	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DQL88_RS08195	1607618..1607833	-	216	WP_001097552.1	hypothetical protein	-
DQL88_RS08200	1607888..1608253	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DQL88_RS08205	1608222..1608467	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DQL88_RS08210	1608517..1608735	-	219	WP_001001383.1	hypothetical protein	-
DQL88_RS08215	1608751..1609306	-	556	Protein_1534	phage antirepressor KilAC domain-containing protein	-
DQL88_RS08220	1609332..1609559	-	228	WP_061642098.1	hypothetical protein	-
DQL88_RS08225	1609731..1610345	+	615	WP_000801423.1	XRE family transcriptional regulator	-
DQL88_RS08230	1610361..1611281	+	921	WP_000348133.1	3'-5' exoribonuclease	-
DQL88_RS08235	1611377..1611559	+	183	WP_000705240.1	hypothetical protein	-
DQL88_RS08240	1611595..1611741	+	147	WP_001794606.1	hypothetical protein	-
DQL88_RS08245	1611738..1612352	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1564832..1631314	66482

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T292200 WP_001025401.1 NZ_LS483301:c1608467-1608222 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT292200 NZ_LS483301:1607888-1608253 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin