Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2377945..2378462 Replicon chromosome
Accession NZ_LS483300
Organism Staphylococcus aureus strain NCTC7485

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag DQL62_RS12325 Protein ID WP_000113263.1
Coordinates 2377945..2378211 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DQL62_RS12330 Protein ID WP_000584499.1
Coordinates 2378211..2378462 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL62_RS12300 2373231..2373767 - 537 WP_000185902.1 GNAT family N-acetyltransferase -
DQL62_RS12305 2374155..2374979 - 825 WP_000594632.1 formate/nitrite transporter family protein -
DQL62_RS12310 2375182..2375364 - 183 WP_000079137.1 hypothetical protein -
DQL62_RS12315 2375451..2375918 - 468 WP_045157501.1 SRPBCC domain-containing protein -
DQL62_RS12320 2376104..2377651 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL62_RS12325 2377945..2378211 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
DQL62_RS12330 2378211..2378462 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL62_RS12335 2378626..2378726 - 101 Protein_2269 hypothetical protein -
DQL62_RS12340 2378733..2379332 - 600 WP_000162810.1 DsbA family protein -
DQL62_RS12345 2379351..2379713 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL62_RS12350 2379968..2381217 + 1250 Protein_2272 FemA/FemB family glycyltransferase FmhA -
DQL62_RS12355 2381314..2382045 - 732 WP_045181277.1 amino acid ABC transporter ATP-binding protein -
DQL62_RS12360 2382042..2382761 - 720 WP_000479577.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T292196 WP_000113263.1 NZ_LS483300:c2378211-2377945 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT292196 WP_000584499.1 NZ_LS483300:c2378462-2378211 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References