Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1528143..1528798 Replicon chromosome
Accession NZ_LS483259
Organism Bordetella pertussis strain BP6242 isolate Bordetella pertussis

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JMW36_RS07335 Protein ID WP_047122780.1
Coordinates 1528143..1528394 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag JMW36_RS07340 Protein ID WP_003809516.1
Coordinates 1528397..1528798 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW36_RS07310 1523304..1524434 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
JMW36_RS07315 1524669..1525250 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
JMW36_RS07320 1525387..1526451 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
JMW36_RS07325 1526536..1526982 - 447 WP_003819827.1 GFA family protein -
JMW36_RS07330 1527207..1528088 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JMW36_RS07335 1528143..1528394 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
JMW36_RS07340 1528397..1528798 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMW36_RS07345 1528818..1529054 + 237 WP_010930404.1 membrane protein -
JMW36_RS07350 1529062..1529541 + 480 WP_010930405.1 disulfide bond formation protein B -
JMW36_RS07355 1529691..1530206 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
JMW36_RS07360 1530209..1531399 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
JMW36_RS07365 1531419..1532456 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
JMW36_RS07370 1532593..1533615 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292152 WP_047122780.1 NZ_LS483259:1528143-1528394 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292152 WP_003809516.1 NZ_LS483259:1528397-1528798 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References