Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2526763..2527418 Replicon chromosome
Accession NZ_LS483252
Organism Bordetella pertussis strain BP82 isolate Bordetella pertussis

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JMW63_RS12100 Protein ID WP_047122780.1
Coordinates 2527167..2527418 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag JMW63_RS12095 Protein ID WP_003809516.1
Coordinates 2526763..2527164 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW63_RS12065 2521946..2522968 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
JMW63_RS12070 2523105..2524142 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
JMW63_RS12075 2524162..2525352 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
JMW63_RS12080 2525355..2525870 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
JMW63_RS12085 2526020..2526499 - 480 WP_010930405.1 disulfide bond formation protein B -
JMW63_RS12090 2526507..2526743 - 237 WP_010930404.1 membrane protein -
JMW63_RS12095 2526763..2527164 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMW63_RS12100 2527167..2527418 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
JMW63_RS12105 2527473..2528354 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JMW63_RS12110 2528579..2529025 + 447 WP_003819827.1 GFA family protein -
JMW63_RS12115 2529110..2530174 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
JMW63_RS12120 2530311..2530892 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
JMW63_RS12125 2531127..2532257 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292139 WP_047122780.1 NZ_LS483252:c2527418-2527167 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292139 WP_003809516.1 NZ_LS483252:c2527164-2526763 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References