Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2526774..2527429 Replicon chromosome
Accession NZ_LS483251
Organism Bordetella pertussis strain BP46 isolate Bordetella pertussis

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JMW30_RS12165 Protein ID WP_047122780.1
Coordinates 2527178..2527429 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag JMW30_RS12160 Protein ID WP_003809516.1
Coordinates 2526774..2527175 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW30_RS12130 2521957..2522979 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
JMW30_RS12135 2523116..2524153 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
JMW30_RS12140 2524173..2525363 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
JMW30_RS12145 2525366..2525881 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
JMW30_RS12150 2526031..2526510 - 480 WP_010930405.1 disulfide bond formation protein B -
JMW30_RS12155 2526518..2526754 - 237 WP_010930404.1 membrane protein -
JMW30_RS12160 2526774..2527175 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMW30_RS12165 2527178..2527429 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
JMW30_RS12170 2527484..2528365 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JMW30_RS12175 2528590..2529036 + 447 WP_003819827.1 GFA family protein -
JMW30_RS12180 2529121..2530185 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
JMW30_RS12185 2530322..2530903 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
JMW30_RS12190 2531138..2532268 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292137 WP_047122780.1 NZ_LS483251:c2527429-2527178 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292137 WP_003809516.1 NZ_LS483251:c2527175-2526774 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References