Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2816616..2817256 Replicon chromosome
Accession NZ_LS399318
Organism Klebsiella pneumoniae isolate CNR48

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag CNR480_RS13445 Protein ID WP_016529833.1
Coordinates 2816616..2816963 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CNR480_RS13450 Protein ID WP_040181955.1
Coordinates 2816963..2817256 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNR480_RS13435 2812542..2813975 + 1434 WP_002920564.1 glycogen synthase GlgA -
CNR480_RS13440 2813993..2816440 + 2448 WP_002920561.1 glycogen phosphorylase -
CNR480_RS13445 2816616..2816963 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNR480_RS13450 2816963..2817256 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
CNR480_RS13455 2817326..2818834 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
CNR480_RS13460 2819039..2819368 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
CNR480_RS13465 2819419..2820249 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
CNR480_RS13470 2820299..2821057 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T292122 WP_016529833.1 NZ_LS399318:2816616-2816963 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT292122 WP_040181955.1 NZ_LS399318:2816963-2817256 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References