Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1585146..1585801 Replicon chromosome
Accession NZ_LS398588
Organism Bordetella pertussis strain VS67 isolate Bordetella pertussis

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag EAO51_RS07750 Protein ID WP_047122780.1
Coordinates 1585146..1585397 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag EAO51_RS07755 Protein ID WP_003809516.1
Coordinates 1585400..1585801 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAO51_RS07725 1580307..1581437 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
EAO51_RS07730 1581672..1582253 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
EAO51_RS07735 1582390..1583454 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
EAO51_RS07740 1583539..1583985 - 447 WP_003819827.1 GFA family protein -
EAO51_RS07745 1584210..1585091 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EAO51_RS07750 1585146..1585397 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
EAO51_RS07755 1585400..1585801 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EAO51_RS07760 1585821..1586057 + 237 WP_010930404.1 membrane protein -
EAO51_RS07765 1586065..1586544 + 480 WP_010930405.1 disulfide bond formation protein B -
EAO51_RS07770 1586694..1587209 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EAO51_RS07775 1587212..1588402 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EAO51_RS07780 1588422..1589459 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
EAO51_RS07785 1589596..1590618 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292106 WP_047122780.1 NZ_LS398588:1585146-1585397 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292106 WP_003809516.1 NZ_LS398588:1585400-1585801 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References