Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2441254..2441438 Replicon chromosome
Accession NC_020564
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAI2T2_RS15090 Protein ID WP_000482652.1
Coordinates 2441331..2441438 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2441254..2441314 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI2T2_RS15075 2436709..2436876 - 168 Protein_2327 hypothetical protein -
SAI2T2_RS12335 2437107..2438840 - 1734 WP_000486483.1 ABC transporter ATP-binding protein/permease -
SAI2T2_RS12340 2438865..2440628 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2441254..2441314 + 61 - - Antitoxin
SAI2T2_RS15090 2441331..2441438 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAI2T2_RS12355 2441572..2441958 - 387 WP_000779360.1 flippase GtxA -
SAI2T2_RS12360 2442226..2443368 + 1143 WP_001176863.1 glycerate kinase -
SAI2T2_RS12365 2443428..2444087 + 660 WP_000831302.1 hypothetical protein -
SAI2T2_RS12370 2444269..2445480 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAI2T2_RS12375 2445603..2446076 - 474 WP_015445934.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T29209 WP_000482652.1 NC_020564:c2441438-2441331 [Staphylococcus aureus subsp. aureus ST228]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T29209 NC_020564:c2441438-2441331 [Staphylococcus aureus subsp. aureus ST228]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT29209 NC_020564:2441254-2441314 [Staphylococcus aureus subsp. aureus ST228]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References