Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3217969..3218471 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name yoeB Uniprot ID D8A584
Locus tag JMX41_RS16105 Protein ID WP_000767828.1
Coordinates 3217969..3218223 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMX41_RS16110 Protein ID WP_001259255.1
Coordinates 3218220..3218471 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS16075 3212984..3213211 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
JMX41_RS16080 3213225..3214283 - 1059 WP_000492324.1 transport protein YeeE -
JMX41_RS16085 3214462..3215820 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMX41_RS16090 3215810..3215872 - 63 WP_010723108.1 membrane protein YoeI -
JMX41_RS16095 3216087..3217016 - 930 WP_000803351.1 LysR family transcriptional regulator -
JMX41_RS16100 3217062..3217886 - 825 WP_000754740.1 SDR family oxidoreductase -
JMX41_RS16105 3217969..3218223 - 255 WP_000767828.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMX41_RS16110 3218220..3218471 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMX41_RS16115 3218754..3218804 + 51 WP_001364200.1 his operon leader peptide -
JMX41_RS16120 3218950..3219849 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMX41_RS16125 3219855..3221159 + 1305 WP_001350335.1 histidinol dehydrogenase -
JMX41_RS16130 3221156..3222226 + 1071 WP_000108947.1 histidinol-phosphate transaminase -
JMX41_RS16135 3222226..3223293 + 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.56 Da        Isoelectric Point: 8.0353

>T292075 WP_000767828.1 NZ_LR898874:c3218223-3217969 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292075 WP_001259255.1 NZ_LR898874:c3218471-3218220 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G465

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References