292074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3204040..3204808 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JMX41_RS16015 Protein ID WP_000854814.1
Coordinates 3204434..3204808 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JMX41_RS16010 Protein ID WP_128857213.1
Coordinates 3204040..3204345 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS15980 3199351..3199896 - 546 WP_000973199.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
JMX41_RS15985 3200361..3200525 - 165 WP_001128468.1 hypothetical protein -
JMX41_RS15990 3201473..3202650 + 1178 WP_152895938.1 IS3 family transposase -
JMX41_RS15995 3202663..3203127 + 465 WP_001571600.1 antirestriction protein -
JMX41_RS16000 3203143..3203619 + 477 WP_001186773.1 RadC family protein -
JMX41_RS16005 3203682..3203903 + 222 WP_000692323.1 DUF987 domain-containing protein -
JMX41_RS16010 3204040..3204345 + 306 WP_128857213.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMX41_RS16015 3204434..3204808 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JMX41_RS16020 3204805..3204999 + 195 WP_000988601.1 hypothetical protein -
JMX41_RS16025 3205012..3205125 + 114 WP_001161660.1 DUF957 domain-containing protein -
JMX41_RS16030 3205414..3205560 - 147 Protein_3146 transposase domain-containing protein -
JMX41_RS16035 3205614..3205796 + 183 WP_001016348.1 hypothetical protein -
JMX41_RS16040 3205897..3206226 - 330 WP_000450409.1 DUF496 family protein -
JMX41_RS16045 3206398..3207456 - 1059 WP_001200894.1 FUSC family protein -
JMX41_RS16050 3207654..3208127 - 474 WP_201555475.1 DNA gyrase inhibitor SbmC -
JMX41_RS16055 3208184..3209404 - 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3208184..3209404 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T292074 WP_000854814.1 NZ_LR898874:3204434-3204808 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11084.76 Da        Isoelectric Point: 5.6182

>AT292074 WP_128857213.1 NZ_LR898874:3204040-3204345 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSGELNPRTQHTVTLYAKGLACEA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure

References