Detailed information of TA system TA292065

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2408802..2409173
• Replicon: chromosome
• Accession: NZ_LR898874
• Organism: Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A1Y2ZGM7
• Locus tag: JMX41_RS11765
• Protein ID: WP_042038331.1
• Coordinates: 2408979..2409173 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2408802..2408980 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX41_RS11740	2404759..2406132	+	1374	WP_000123722.1	ATP-dependent RNA helicase DbpA	-
JMX41_RS11745	2406261..2407196	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
JMX41_RS11750	2407248..2408481	-	1234	Protein_2303	site-specific integrase	-
JMX41_RS11755	2408483..2408698	-	216	WP_000079604.1	excisionase XisR	-
JMX41_RS11760	2408798..2408986	-	189	WP_001302840.1	DUF1187 family protein	-
-	2408802..2408980	+	179	NuclAT_0	-	Antitoxin
-	2408802..2408980	+	179	NuclAT_0	-	Antitoxin
-	2408802..2408980	+	179	NuclAT_0	-	Antitoxin
-	2408802..2408980	+	179	NuclAT_0	-	Antitoxin
JMX41_RS11765	2408979..2409173	-	195	WP_042038331.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
JMX41_RS11770	2409230..2410039	-	810	WP_000166319.1	recombination protein RecT	-
JMX41_RS11775	2410032..2412632	-	2601	WP_000105133.1	exodeoxyribonuclease VIII	-
JMX41_RS11780	2412734..2413009	-	276	WP_000632297.1	protein RacC	-
JMX41_RS11785	2413084..2413254	-	171	WP_001485242.1	hypothetical protein	-
JMX41_RS11790	2413254..2413475	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2407248..2417188	9940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7046.94 Da
• Isoelectric Point: 8.9538

>T292065 WP_042038331.1 NZ_LR898874:c2409173-2408979 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKVISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

Antitoxin

Nucleotide

• Length: 179 bp

>AT292065 NZ_LR898874:2408802-2408980 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A1Y2ZGM7

Antitoxin