Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 644473..645272 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JMX41_RS03140 Protein ID WP_000347273.1
Coordinates 644473..644937 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A210GLR0
Locus tag JMX41_RS03145 Protein ID WP_001571956.1
Coordinates 644937..645272 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS03110 639474..639908 - 435 WP_000948834.1 PTS sugar transporter subunit IIA -
JMX41_RS03115 639926..640804 - 879 WP_001330129.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMX41_RS03120 640794..641573 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMX41_RS03125 641584..642057 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMX41_RS03130 642080..643360 - 1281 WP_000681958.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMX41_RS03135 643609..644418 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMX41_RS03140 644473..644937 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMX41_RS03145 644937..645272 - 336 WP_001571956.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMX41_RS03150 645421..646992 - 1572 WP_001571955.1 galactarate dehydratase -
JMX41_RS03155 647367..648701 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMX41_RS03160 648717..649487 + 771 WP_001058217.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T292056 WP_000347273.1 NZ_LR898874:c644937-644473 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12328.96 Da        Isoelectric Point: 4.6647

>AT292056 WP_001571956.1 NZ_LR898874:c645272-644937 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQITRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A210GLR0

References