Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1716741..1717243 Replicon chromosome
Accession NZ_LR898868
Organism Escherichia coli isolate MSB1_1D-sc-2280324

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMX26_RS08140 Protein ID WP_000767829.1
Coordinates 1716989..1717243 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMX26_RS08135 Protein ID WP_001259255.1
Coordinates 1716741..1716992 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX26_RS08110 1711919..1712986 - 1068 WP_130053447.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMX26_RS08115 1712986..1714056 - 1071 WP_053889089.1 histidinol-phosphate transaminase -
JMX26_RS08120 1714059..1715357 - 1299 WP_001743908.1 histidinol dehydrogenase -
JMX26_RS08125 1715363..1716262 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMX26_RS08130 1716408..1716458 - 51 WP_001364200.1 his operon leader peptide -
JMX26_RS08135 1716741..1716992 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMX26_RS08140 1716989..1717243 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMX26_RS08145 1717326..1718150 + 825 WP_130053448.1 SDR family oxidoreductase -
JMX26_RS08150 1718196..1719125 + 930 WP_000803366.1 LysR family transcriptional regulator -
JMX26_RS08155 1719340..1719402 + 63 WP_010723108.1 membrane protein YoeI -
JMX26_RS08160 1719392..1720750 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMX26_RS08165 1720929..1721987 + 1059 WP_000492327.1 transport protein YeeE -
JMX26_RS08170 1722001..1722228 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T292037 WP_000767829.1 NZ_LR898868:1716989-1717243 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292037 WP_001259255.1 NZ_LR898868:1716741-1716992 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References