Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 601554..602335 Replicon chromosome
Accession NZ_LR898868
Organism Escherichia coli isolate MSB1_1D-sc-2280324

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag JMX26_RS02920 Protein ID WP_113417943.1
Coordinates 601554..602000 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JMX26_RS02925 Protein ID WP_001307405.1
Coordinates 602000..602335 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX26_RS02895 596990..597868 - 879 WP_130053258.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMX26_RS02900 597858..598637 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMX26_RS02905 598648..599121 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMX26_RS02910 599144..600424 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMX26_RS02915 600672..601481 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMX26_RS02920 601554..602000 - 447 WP_113417943.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMX26_RS02925 602000..602335 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMX26_RS02930 602484..604055 - 1572 WP_130053259.1 galactarate dehydratase -
JMX26_RS02935 604430..605764 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JMX26_RS02940 605780..606550 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-147)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 149 a.a.        Molecular weight: 17109.55 Da        Isoelectric Point: 10.0993

>T292032 WP_113417943.1 NZ_LR898868:c602000-601554 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTR

Download         Length: 447 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT292032 WP_001307405.1 NZ_LR898868:c602335-602000 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References