Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5875867..5876462 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag JMX72_RS27565 Protein ID WP_003113526.1
Coordinates 5876184..5876462 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag JMX72_RS27560 Protein ID WP_003111575.1
Coordinates 5875867..5876172 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS27530 5870913..5871185 - 273 WP_004352675.1 hypothetical protein -
JMX72_RS27535 5871632..5871923 + 292 Protein_5442 hypothetical protein -
JMX72_RS27540 5871975..5873534 - 1560 WP_201720842.1 SIR2 family protein -
JMX72_RS27545 5873548..5873919 - 372 WP_079280107.1 ASCH domain-containing protein -
JMX72_RS27550 5873897..5874949 - 1053 WP_023084818.1 hypothetical protein -
JMX72_RS27555 5874967..5875488 - 522 WP_201720843.1 AAA family ATPase -
JMX72_RS27560 5875867..5876172 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
JMX72_RS27565 5876184..5876462 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX72_RS27570 5876791..5879019 + 2229 WP_033991161.1 TonB-dependent receptor -
JMX72_RS27575 5879090..5879737 - 648 WP_003095021.1 carbonate dehydratase -
JMX72_RS27580 5879799..5881037 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T292031 WP_003113526.1 NZ_LR898867:c5876462-5876184 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT292031 WP_003111575.1 NZ_LR898867:c5876172-5875867 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References